CORONAVIRUS UPDATE: PREVENTION, TREATMENT AND LESSONS LEARNED

The following information is based on a lecture by Dietrich Klinghardt MD, PhD (3-19-2020) as well as the research of Judy Mikovits, PhD

Dr. Klinghardt is a distinguished clinician and researcher in integrative medicine.  His website is https://www.sophiahi.com/meet-the-team/dietrich-klinghardt-md-phd/

Dr. Mikovitz is a former scientist at the National Cancer Institute and later the director of the Cancer Biology program at EpiGenX Pharmaceuticals in Santa Barbara, California. There in 2006, she became attracted to the plight of patients with Chronic Fatigue Syndrome and Autism. In only five years she developed the first neuroimmune institute from a concept to a reality and is primarily responsible for demonstrating the relationship between immune based inflammation and these diseases. She has published over 50 scientific papers. Dr. Mikovits spoke the truth about the fraudulent use of government research money, the marketing of inaccurate retrovirus tests, Medicare fraud, the contaminated blood supply, and the harm that is associated with vaccines and their schedule of administration. Her research showed how retroviruses are linked to the plague of modern illnesses that are bankrupting the U.S. healthcare system. She was arrested without a warrant and held in jail for 5 days without the opportunity for bail as a fugitive from justice. Her career was destroyed.

She is the author of: Plague: One Scientist’s Intrepid Search for the Truth about Human Retroviruses and Chronic Fatigue Syndrome (ME/CFS), Autism, and Other Diseases, by Judy Mikovits and Kent Heckenlively

  LESSONS FROM WUHAN – 2019-2020 Outbreak

As of March 6, 2020, COVID-19 has been confirmed in more than 100,000 individuals (mostly in China) and has resulted in more than 3,400 deaths. Outside of China, infections have been reported in an increasing number of countries

In an initial report of 41 patients infected in Wuhan, China, Dr. Huang reported:

  • 78% male predominance,
  • 32% of all patients reporting underlying disease.

The most common clinic findings were:Mild to moderate fever (98%),

  • Dry cough (76%)
  • muscles aches and fatigue (44%).
  • Headache, sputum production, and diarrhea were less common.

The clinical course was characterized by:

  • Dyspnea (shortness of breath) in 55% of patients
  • Lymphocytopenia (immune cells that make antibodies to protect you from infection) in 66%.
  • Chest radiography: Chest radiography may reveal pulmonary infiltrates
  • Acute respiratory distress syndrome (ARDS) developed in 29% of patients

The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health – The latest 2019 novel coronavirus outbreak in Wuhan, China. Hui et al.  Int J Infect Dis. 2020 Jan 14. 91:264-266.

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Huang C, et al. Lancet. 2020 Jan 24

WASHINGTON STATE CORONAVIRUS DEATHS AND WI-FI

As of March 21, 2020, 85 deaths have occurred and 6 of them occurred in Evergreen Hospital, in Kirkland, WA, which prides itself as being one of the first towns in the US wired for 5G. According to Dr. Klinghardt, Evergreen hospital has the highest levels of Wi-Fi exposure ever measured in a hospital.

READ MORE  https://www.healmindbody.com/knowledges/5g-wi-fi-and-emf-damaging-effects-on-the-body/

EFFECTIVE ANTI-VIRAL TREATMENTS

According to a consensus statement from a multicenter collaboration group in China, chloroquine phosphate 500-mg twice daily in tablet form for 10 days may be considered in patients with COVID-19 pneumonia

Expert consensus on chloroquine phosphate for the treatment of novel coronavirus pneumonia’

Multicenter collaboration group of Department of Science and Technology of Guangdong Province and Health Commission of Guangdong Province for chloroquine in the treatment of novel coronavirus pneumonia.  Zhonghua Jie He He Hu Xi Za Zhi. 2020 Feb 20. 43:E019

The same article also highlights the in-vitro effectiveness or Nitazoxanide (Alinia, Daxon) next to chloroquine. Alinia is very well tolerated and familiar to our patients.

It was also found very effective in treating the more deadly MERS-corona virus.

Nitazoxanide, a new drug candidate for the treatment of Middle East respiratory syndrome coronavirus, Journal of Infection and Public Health. Volume 9, Issue 3, May–June 2016, Pages 227-230; Jean-François Rossignol

Recent guidelines from South Korea and China report that chloroquine is an effective antiviral therapeutic treatment against Coronavirus Disease 2019.  Use of chloroquine (tablets) is showing favorable outcomes in humans infected with Coronavirus including faster time to recovery and shorter hospital stay.  US CDC research shows that chloroquine also has strong potential as a prophylactic (preventative) measure against coronavirus in the lab, while we wait for a vaccine to be developed.  Chloroquine is an inexpensive, globally available drug that has been in widespread human use since 1945 against malaria, autoimmune and various other conditions.

As chloroquine is not available in Korea, doctors could consider hydroxychloroquine 400mg orally per day (Hydroxychloroquine is an analog of chloroquine used against malaria, autoimmune disorders, etc.  It is widely available as well).

The treatment is suitable for 7 – 10 days, which can be shortened or extended depending on clinical progress.

Effective Treatment for Coronavirus (COVID-19) March 13, 2020 James M. Todaro, MD and Gregory J. Rigano, Esq. In consultation with Stanford University School of Medicine, UAB School of Medicine and National Academy of Sciences.

A recent well controlled clinical study conducted by Didier Raoult M.D, Ph.D, et. al in France has shown that 100% of patients that received a combination of hydroxychloroquine and Azithromycin tested negative and were cured within 6 days of treatment.

Results of a study on 40 patients – 20 patients in treatment group, 20 cures)

  • Six patients were asymptomatic,
  • 22 had upper respiratory tract infection symptoms
  • eight had lower respiratory tract infection symptoms.
  • Twenty cases were treated in this study and showed a significant reduction of the viral carriage at Day 6-post inclusion compared to controls, and much lower average carrying duration than reported of untreated patients in the literature.
  • Azithromycin added to hydroxychloroquine was significantly more efficient for virus elimination

Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical. Gautret et al. (2020) International Journal of Antimicrobial Agents – In Press 17 March 2020 – DOI : 10.1016/j.ijantimicag.2020.105949

GENERAL MEASURES FOR PREVENTION OF VIRAL RESPIRATORY INFECTIONS

  • Hand washing with soap and water for at least 20 seconds. A 60% alcohol-based hand sanitizer may be used if soap and water are unavailable.
  • Individuals should avoid touching their eyes, nose, and mouth with unwashed hands.
  • Individuals should avoid close contact with sick people.
  • Sick people should responsibly self-isolate/ stay at home (e.g., from work, school).
  • Coughs and sneezes should be covered with a tissue, followed by disposal of the tissue in the trash.
  • Frequently touched objects and surfaces should be cleaned and disinfected regularly.
  • Following the model of the Hong Kong protocol citizens are advised to wear facial masks at all times when in the presence of other people both as a means of protection and spread of the virus

PREVENTING VIRAL REPLICATION IN THE BODY

Covid-19 can survive 72 hrs. (some estimate up to 7 days) on surfaces outside the body. Disinfecting is crucial!

Once inside the body, Covid-19 lives mostly on the surface of tissues.  The virus replicates itself in the throat during the first 5 days after symptoms onset. With the first signs of fever, sore throat, unwellness, use propolis tincture – alternating with BRIOTECH Topical Skin Spray frequently onto the sore throat area. Also spray BRIOTECH Topical Skin Spray in the eyes and nose (hourly or more often)

Propolis stimulates anti-viral immunity in mucous membranes

BRIOTECH Topical Skin Spray is electrically charged to support your skin against irritations, inflammation and post-procedure sensitivities.  It is an all-natural and potent signaling solution that mimics the essence of human healing.

Effect of the ethanolic extract from green propolis on production of antibodies after immunization against canine parvovirus (CPV) and canine coronavirus (CCoV). Ferreira, L. das N., et al., Brazilian Journal of Veterinary Research and Animal Science 49.2 (2012): 116-121)

STABILIZED HOCL: POWERFUL HEALING AGENT MADE NATURALLY IN YOUR BODY

HOCL (hypochlorous acid) is made naturally in the white blood cells as a key component of the internal defense system, working to fight against infection, reduce inflammation, control responses to injury, and enhance the healing process.

BRIOTECH Topical Skin Spray is safe to use anywhere you have skin. It is a highly effective and potent signaling solution that mimics the essence of human healing. This perfect, all-natural, cosmetic solution is electrically charged to support your skin against irritations, inflammation and post-procedure sensitivities; may be used throughout the day for all your topical applications, from head to toe.

Viral shedding lasted 31 and 19 days from symptom onset in two patients with east respiratory syndrome coronavirus (MERS-CoV) pneumonia, respectively. Environmental real-time RT-PCR was weakly positive for bed guardrail and monitors. Even after cleaning the monitors with 70% alcohol-based disinfectant, RT-PCR was still weakly positive, and converted to negative only after wiping with diluted sodium chlorite. Further studies are required to clarify the appropriate methods to clean environments during and after treatment of patients with MERS-CoV infection.

Song, Joon Young, et al. “Viral shedding and environmental cleaning in Middle East respiratory syndrome coronavirus infection.” Infection & chemotherapy 47.4 (2015): 252-255.

A recent certificate from UW: 3/4/2016

“As part of our ongoing collaboration with Briotech Inc, in Washington, my microbiology laboratory has been evaluating the efficacy of BrioHOCl against human coronavirus OC43. Studies conducted to date indicate at least a 99.999% reduction in the infectivity of human coronavirus upon 10 min exposure to BrioHOCl solution. Further work is underway to characterize this important finding.”

John Scott Meschke PhD, Professor and Director of Environmental and Occupational Health Microbiology Lab Department of Environmental and Occupational Health Sciences School of Public Health, University of Washington

CURRENT PROMISING TREATMENTS

Vitamin C

In a press release from a Chinese hospital specializing in infectious disease it was observed that intravenous vitamin C was extremely effective in treating affected and infected patients. The dose of 100-200 mg/kg body weight was given intravenously for 3 days in a row ( this equals to only 7.5 – 15 grams for a 75 kg (180 lbs.)

Vitamin C: Ascorbic acid can dose-dependently inhibit NLRP3 Inflammasomes both in vitro and in vivo, decreasing IL-1β secretion, without inducing any cytotoxic effects nor cell death (Vitamin C inhibits the activation of the NLRP3 inflammasome by scavenging mitochondrial ROS https://www.researchgate.net/publication/305624280)

In the US, the pioneers of orthomolecular medicine also published a consensus paper on the use of Vit C: Orthomolecular Medicine News Service, Feb 16, 2020 “Early Large Dose Intravenous Vitamin C is the Treatment of Choice for 2019-nCov infected Pneumonia” Richard Z Cheng, MD, PhD; Hanping Shi, MD, PhD; Atsuo Yanagisawa, MD, PhD; Thomas Levy, MD, JD; Andrew Saul, PhD.

Summary: take a minimum of 2000 mg Vitamin C per day

Nitazoxanide (Alinia) 1000mg twice daily for 10 days. Nitazoxanide is usually well tolerated.

Chloroquine phosphate (Plaquenil): 500 mg twice daily for 10 days. Your physician will monitor for side effects.

FURIN INHIBITION USING ANDROGRAPHIS AND VITAMIN C

Furins are a family of enzymes in the body that convert precursor proteins into their biologically active products so they can be used in metabolic pathways. However, furin is also utilized by a number of pathogens such as influenza, HIV, ebola, and corona virus, to become fully functional. They need the furin enzyme to enter human cells. Therefore, inhibitors of furin are under consideration as therapeutic agents for treating many infectious diseases including CoV.

The furin cleavage allows efficient virus entry into basically all cell types, making the COVID-19 easily transmissible at rates up to 1,000 times greater than the virulent SARS coronavirus.

The presence of furin enzymes on all cell surfaces cleaves and activates the SARS-CoV-2 in a wide range of tissues and organs. Activated SARS-CoV-2 then unleashes NLRP3 inflammasomes, initiating a flurry of immune reactions that can result in deadly cytokine storms.

Andrographis paniculata is a powerful anti-furin strategy and should be utilized early in the treatment of infected or suspected individuals.

Inhibition of proprotein convertases-1,-7 and furin by diterpines of Andrographis paniculata and their succinoyl esters. Basak, Ajoy, et al. Biochemical Journal 338.1 (1999): 107-113.

Inhibitors of proprotein convertases. Basak, Ajoy. Journal of molecular medicine 83.11 (2005): 844-855.

Vitamin C has also been shown to have anti-furin properties

COVID-19, Furins & Hypoxia – The Vitamin C Connection

https://www.evolutamente.it/covid-19-furins-cancer-a-tale-of-vita

MELATONIN – REDUCING INFLAMMATION AND ENHANCING IMMUNITY

What makes Covid-19 potentially lethal is the activation of the inflammasome triggering the dreaded “cytokine storm”. Inflammasomes are innate immune system receptors/sensors that induce inflammation in response to infectious microbes. Covid-19 activation of the inflammasome promotes the secretion of pro-inflammatory cytokines interleukin 1β (IL-1β) and interleukin 18 (IL-18) which can lead to lung alveolar destruction and Acute Respiratory Distress Syndrome.

Melatonin has recently been shown to reduce the inflammatory cytokine, IL-1β, and attenuate inflammasome-associated vascular disorders by improving endothelial leakage and suppressing NLRP3 inflammasomes

Melatonin inhibits inflammasome-associated activation of endothelium and macrophages attenuating pulmonary arterial hypertension. | Cardiovascular Research | Oxford Academic

https://academic.oup.com/cardiovascres/advance-article-abstract/doi/10.1093/cvr/cvz312/5644338?

This also means that if a patient, regardless of age, has adequate melatonin, the infectiousness of COVID-19 will be greatly reduced, and the chances of developing acute respiratory distress will be significantly diminished. Melatonin is the reason why children under the age of 9 seldom exhibit severe symptoms. In fact, children may exhibit mild or even no symptoms at all, even though they have been infected by SARS-CoV-2

Coronavirus Disease-2019 (COVID-19) and Children  https://www.cdc.gov/coronavirus/2019-ncov/specific-groups/children-faq.html)

In rodent models of acute respiratory distress syndrome (ARDS), combined treatment of melatonin and mitochondria significantly attenuated progression of ARDS (Systemic combined melatonin–mitochondria treatment improves acute respiratory distress syndrome in the rat

Journal of Pineal Research – Wiley Online Library https://onlinelibrary.wiley.com/doi/10.1111/jpi.12199)

The critical function of suppressing cytokine storms to prevent progression of acute respiratory distress syndrome (ARDS) and respiratory failure in infected patients was clearly demonstrated in a study by Huang et al. (2019). Co-treatment of these infected rodents with melatonin and an antiviral drug significantly increased their survival rates compared to mice treated only with antivirals alone.

Melatonin possesses an anti-influenza potential through its immune modulatory effect – ScienceDirect https://www.sciencedirect.com/science/article/pii/S1756464619302452

None of the pregnant mothers infected by COVID-19 admitted to Zhongnan Hospital of Wuhan University, Wuhan, China,  developed severe pneumonia or died; nor were their babies infected by COVID-19

Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records – The Lancet https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30360-3/fulltext

Why is mom and baby protected? Melatonin secretion in the third trimester of pregnancy is more than doubled compared to the first trimester.

Role of melatonin in embryo fetal development. Voiculescu SE, et al AM. J Med Life. 2014;7(4):488–492.)

The death rate of this virus is dependent on age. That is very different from the regular winter flu viruses who are equally dangerous to infants and older people.

Recent reports of younger people dying of covid-19 appear to relate to individuals exposed to high levels of WiFi/EMF – which is a major cause of decreased melatonin levels.

The LANCET – Infectious Diseases; March 12, 2020

Real Estimates of Mortality following COVID-19 infection; David Baud; Xiaolong Qi et al

NITRIC OXIDE SUPPRESSES INFLAMMATION

In rodent sepsis models, nitric oxide was demonstrated to inhibit NLRP3 activation (Nitric oxide suppresses NLRP-3 inflammasome activation and protects against LPS-induced septic shock

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567828/

Nitric oxide produced in nasal passages is part of the defense system against bacterial and viral infections

High Nitric Oxide Production in Human Paranasal Sinuses – PubMed https://pubmed.ncbi.nlm.nih.gov/7585069-high-nitric-oxide-production-in-human-paranasal-sinuses/?dopt=Abstract

Newborns have been found to have an extremely high level of nitric oxide in their barely developed paranasal sinuses

Infant nasal nitric oxide over time: natural evolution and impact of respiratory tract infection | European Respiratory Society  https://erj.ersjournals.com/content/51/6/1702503

Vit C increases NO (COVID-19 Mutations, Vaccines & Nitric Oxide – The Vitamin C Connection – EvolutaMente.it

https://www.evolutamente.it/covid-19-mutations-vaccines-nitric-oxide-the-vitamin-c-connection/

Simple Humming while exhaling instantly increases the nitric oxide concentration in the nasal passages and sinuses – the very tissues, where covid-19 lingers for many days before infecting other tissues

Humming greatly increases nasal nitric oxide. Weitzberg, E. et al, Am J of respiratory and critical care medicine 166.2 (2002): 144-145.

 

 

MORE INFORMATION ON NITRIC OXIDE

https://www.healmindbody.com/nitric-oxide-master-molecule-for-health-and-longevity/

STOP ANGIOTENSIN CONVERTING ENZYME INHIBITORS – AND SELENIUM

Angiotensin-converting enzyme, or ACE, is a central component of the renin–angiotensin system, which controls blood pressure by regulating the volume of fluids in the body. It converts the hormone angiotensin I to the active vasoconstrictor angiotensin II.

SARS-CoV-2 infects host cells through binding with ACE-2 receptors.

Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS | Journal of Virology https://jvi.asm.org/content/early/2020/01/23/JVI.00127-20

ACE inhibitors are medications, like Capoten (captopril) Vasotec (enalapril) Prinivil, Zestril (lisinopril) and Lotensin (benazepril) are used to treat hypertension. They are effective and believed to be safe. However, they are known to increase expression of ACE-2 and therefore are known to increase the virulence of the virus.

SELENIUM:

Most integrative practitioners believe that selenium is a safe treatment with anti-viral properties. However, it is little known, that nutritional selenium may also be an effective inhibitor of angiotensin-converting enzyme (ACE)

Inhibition of angiotensin-converting enzyme by selenoneine | SpringerLink https://link.springer.com/article/10.1007/s12562-019-01321-3?

Using ACE inhibitors either through medication or supplements may risk elevating COVID-19 infection and developing severe or even fatal disease complications.

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? – The Lancet Respiratory Medicine https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30116-8/fulltext?

THE TWO MAIN ORTHOMOLECULAR TREATMENTS FOR CORONAVIRUS INFECTION

Melatonin:

take 50mg at bedtime and 2 to 3 hours AFTER your last meal.

You should ideally finish eating before it is dark. It is also extremely helpful if you can lower your ambient lighting at night, as the lowest amount of light will disrupt melatonin production.  Melatonin is produced in all cells, including mitochondria, not just in pineal glands.  IF you are diabetic, or have insulin resistance, DO NOT TAKE MELATONIN before 3 pm. – melatonin can suppress insulin.

DAYTIME – 40% of total daily dose, divided into small equal portions to be taken every TWO HOURS (orally).

NIGHTTIME – 60% of total daily dose, divided into two portions taken 2-3 hours after dinner.  The final dose at night should be completed by 10 pm.

Vitamin C:

If you are older or more susceptible to COVID-19 for various reasons, your maintenance dose should be one gram per hour, to total 10-18 grams per day, depending on your tolerance level.  You will experience loose stools, or what is known as hitting Bowel Tolerance if you have saturated your system with ascorbic acid.

Ascorbic Acid COVID-19 Infection Dosage:

1 gram every 15 to 30 minutes, depending on severity of symptoms.

Increase to 2 grams every 15 to 30 minutes if symptoms are not reversed within 12-24 hours.

IF you are infected, you will essentially have an ‘unlimited’ tolerance for ascorbic acid.  Your tolerance may increase above 100 grams or more. That is normal.

If available, use intravenous Vitamin C (7.5 grams – 50 grams/day) on 3 consecutive days

SUMMARY OF RECOMMENDATIONS

  • Use your HOCL inhaler frequently during the day. Also spray your eyes, inside of your mouth. Use a fogger in your home once daily to create HOCL mist in the air, settling on all surfaces. Take HOCL with you and use in restaurants, workplace, coffee shop, dentist’s office, etc.
  • Use Propolis tincture inside your mouth alternating with HOCL. Use the propolis vaporizer (www.KiScience) in each room of your home for several hours/day. Alternate with HOCL. Change your clothes after being outside and don’t reuse for 72 hours. Keep your shoes outside.
  • Use Vitamin C every hour.
  • Keep your Vitamin D level high normal
  • Food: During infection, rest, drink plenty of purified water.  You may lose your appetite. Do not force yourself to eat if you are not hungry.  Calorie restriction initiates mitophagy and autophagy, which will facilitate healing.
  • Do not use NSAIDS, such as ibuprofen, which have been shown in children to possibly increase risk of lung complications.

Nonsteroidal anti-inflammatory drug without antibiotics for acute viral infection increases the empyema risk in children: a matched case-control study. The Journal of pediatrics, 175, 47-53 (2016); Bourgeois, M.,et al